‘Exceptional responders’ may avoid breast cancer surgery

Patients with early-stage breast cancer who had a pathologic complete response (pCR) to neoadjuvant chemotherapy may be able to skip surgery and receive standard radiation treatment with a low chance of disease recurrence, according to a new study from researchers at The University of Texas MD Anderson Cancer Center.

The Phase II trial results, published in Lancet Oncology, evaluated the likelihood of breast cancer returning in patients who are in complete remission after receiving chemotherapy and radiation without surgery.

Each of the 31 patients followed had a complete response to chemotherapy and none had a breast tumour recurrence after a median follow-up of 26.4 months.

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